In some cultures, adding toé to an ayahuasca brew is a traditional element of the ayahuasca ceremony. But with the growth of ayahuasca tourism has come a rush of underqualified or even pseudo shamans looking to cash in on the boom. And in these settings, the brews may be mostly made up of datura with little to no ayahuasca at all, which, given datura’s risk level, can be dangerous. Whether embarking on a toé journey or an ayahuasca ceremony, it’s important to vet the retreat and acting shaman in order to avoid a dangerous situation. It also doesn’t hurt to ask even reputable places what exactly they’re putting in their brew.
Fatal overdoses and adverse reactions are very common with datura. Advocates of the plant rarely recommend it without extreme caution.
You can listen to Dr. David Luke’s interview below or Click here to read the transcript
 Wyrd. (2004, Nov 13). A Rebirth: An Experience with Datura (ID 16973). Retrieved from https://erowid.org/experiences/exp.php?ID=16973.
Datura innoxia is often found as toloache in the witches’ markets of Mexico and Latin America, to be used in neo-shamanic divination or love magic.  In Tanzania, Datura is applied as a topical anti-inflammatory or added to pombe beer to induce hallucinations.  It’s also heavily cultivated in a number of tropical African countries for use in pharmaceuticals, pesticides, and bioremediation projects (e.g. filtering waste from contaminated soil).  
In Colombia, scopolamine has allegedly been slipped into people’s drinks by opportunistic thieves. Apparently, this gives them complete control over their victims’ behavior, with no outward appearance of coercion. 
Kurzbaum, A., Simsolo, C., Kvasha, L., and Blum, A. Toxic delirium due to Datura stramonium. Isr.Med.Assoc.J 2001;3(7):538-539. View abstract.
Alebiowu, G., Femi-Oyewo, M. N., Elujoba, A. A., and Ojo, O. S. Toxicity studies on Datura metel L. with reference to official stramonium. J Herb.Pharmacother. 2007;7(1):1-12. View abstract.
Some of these drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).
Koevoets, P. F. and van Harten, P. N. [Thorn apple poisoning]. Ned.Tijdschr.Geneeskd. 5-3-1997;141(18):888-889. View abstract.
Toxic megacolon: In this life-threatening condition, the large intestine (colon) suddenly becomes extra wide because of an infection or other intestinal disorder. Taking jimson weed might make this condition worse.
Pavlov, A., Berkov, S., Weber, J., and Bley, T. Hyoscyamine Biosynthesis in Datura stramonium Hairy Root In Vitro Systems with Different Ploidy Levels. Appl Biochem Biotechnol 5-29-2008; View abstract.
Spina, S. P. and Taddei, A. Teenagers with Jimson weed (Datura stramonium) poisoning. CJEM. 2007;9(6):467-468. View abstract.
A moderate datura dose lasts eight to 12 hours, while strong doses can cause effects lasting for two to three days.
Scopolamine and atropine are anticholinergic deleriants. They block muscarinic receptors, which in turn excite dopaminergic neurons. They are readily absorbed, partially metabolised by the liver, and mostly eliminated in urine, with a half-life of about four hours.
The main active chemicals present in datura are tropane alkaloids scopolamine, atropine, and hyoscamine.
Unlike the visual effects frequently reported with psychedelics such as LSD and psilocybin-containing mushrooms, datura causes frank hallucinations, meaning that the person cannot distinguish between the hallucinations and real objects. Elaborate visions and fantasies are common, sometimes including long conversations with imaginary persons. Smoking phantom cigarettes is often reported, even by non-smokers.
Datura seeds and flowers are usually more potent than the leaves and roots. Potency increases over the reproductive period and peaks while the plant is fruiting. As few as 10 datura seeds taken orally or one leaf brewed into a tea can produce profound perceptual changes, and 30-40 seeds is an extremely potent dose.
Datura is not believed to be physically addicting nor likely to cause psychological dependence. Withdrawal effects following discontinuation have not been reported.
– Article used with the permission of Erowid.org. Last modified April 2009.