Dogs receiving chemotherapy for cancer tend to have a lot of unwanted side effects. Many pet parents use CBD oil as a way to curb some of them and make their pet more comfortable. Recent research has shown that giving CBD oil to your pet in conjunction with radiation actually may make chemotherapy more effective. CBD and Gabapentin For Dogs: Can Dogs Take CBD and Gabapentin? Cannanine™ Ultra-Premium Hemp Oil (250mg, 500mg, 1000mg) $69.99 – $129.99 $39.99 – $99.99 The most potent and cost effective What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.
What Drugs Will Interact with My Pet’s CBD?
While we still do not even know the extent that people’s medications will interact with CBD, even less is known about pet CBD medication interactions. That is simply because the research is lacking for both, especially in the pet field.
My veterinarian will not talk to me about CBD, but I would still like to make an educated decision on whether or not giving them CBD would be for the best.
We understand that this can be a very frustrating issue for a lot of pet parents. While CBD can cause some pet medications to be more or even less effective if consumed with CBD, there are similar precautions that have to be taken when giving your pet herbal supplements or even vitamins. There is always going to be a chance of interactions. The extent of them depends on body chemistry and prescription dose. What will affect one pet, may not affect another.
When CBD is ingested orally at large doses a group of liver enzymes in your pet may be temporarily altered. One of the most common interactions that relate to this is grapefruit for humans. CBD is also metabolized by cytochrome P450 enzymes preventing it from metabolizing other compounds.
“The extent to which cannabidiol behaves as a competitive inhibitor of cytochrome P450 depends on how tightly CBD binds to the active site of the metabolic enzyme before and after oxidation. This can change greatly, depending on how – and how much – CBD is administered, the unique attributes of the individual taking this medication, and whether isolated CBD or a whole-plant remedy is used.” – Adrain Devitt-Lee, a researcher at Project CBD.
60% of all medications are metabolized in the liver via specific enzymes produced in it. CBD, like grapefruit, temporarily uses up the enzymes and/or inhibiting the action of others.
Drugs that may be used for pain relief in your pet such as NSAIDs (anti-inflammatory drugs), Tramadol, Gabapentin or anxiety relief such as Prozac all rely on the P450 enzymes. This does not mean your pet can’t take CBD, it just means you might want to be a little more careful when dosing it at first. And CBD can be a wonderful way to hopefully have your pet use less of the above medications.
NSAIDs can wreak havoc on the stomach and liver over long term use.
Tramadol and Gabapentin usually require an increased dose over time because the body gets used to it.
Prozac and any other anti-anxiety will have withdrawal symptoms if given over a period of time. Please do not ever take your pet off of these medications cold-turkey. It is very very important your pet is titrated down slowly off of them.
Here is how one of our clients uses CBD and Prozac together-
“I give my dog Blooming Culture pet CBD oil on a daily basis to help with her generalized anxiety. When we travel or fly I up her dose of CBD that day and add in her veterinarian prescribed Prozac. I have found in conjunction they work really well together for extreme circumstances.”
One of the biggest known and visible side-effects of dosing your pet CBD with any of these medications is tiredness, which can be easily remedied by adjusting their dose.
If you are thinking about switching your pet off their prescription medication or trying to lower their dose, do it slowly. You can first start with a low dose of CBD and talking to your veterinarian on the best way to ween off the particular medication.
All Drug Interactions are Not Negative
Since CBD can also enhance the effects of certain medications, this means that a lower dose of that medication or therapy can sometimes be used, which is a positive.
Drugs used for dog seizures is one. Since CBD also has its own anti-seizure properties, it has proven to work well in human clinical trials together with anti-seizure medications. The AKC Health Foundation recently announced that it will begin a major clinical trial to study the potential for pet CBD oil for use in drug-resistant epileptic dogs.
The second is chemotherapy. Dogs receiving chemotherapy for cancer tend to have a lot of unwanted side effects. Many pet parents use CBD oil as a way to curb some of them and make their pet more comfortable. The same way people going through radiation may use CBD or cannabis. But recent research has shown that giving CBD oil to your pet in conjunction with radiation actually may make chemotherapy more effective.
Some research states that CBD triggers TRPV2 channels, making the cancer cells more sensitive to chemotherapy.
A different study showed that rats with pancreatic cancer had 3X the survival rate when given CBD in conjunction with chemotherapy instead of only chemotherapy.
Again, please work with your veterinarian as much as possible to make sure every medication, natural or not is working together safely on your pet.
*This article is for informational purposes only. If you have pet medication interaction concerns, please always consult with your veterinarian first.
CBD and Gabapentin For Dogs: Can Dogs Take CBD and Gabapentin?
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Gabapentin vs CBD Oil for Dogs
In the last 2 years, the popularity of cannabidiol (CBD) has exploded in popularity for dog owners seeking to manage pain & anxiety. CBD is often touted by some as a miracle drug, capable of curing nearly any ailment. The truth, however, is much more nuanced and while the industry is plagued by unrealistic promises for using CBD, actual research backed science is emerging that shows great promise for this hemp based compound.
In this beginner’s guide, we’ll introduce you to canine pain management using CBD. We’ll cover topics on the safety and legality of CBD, what scientific studies have shown, the success rates of using CBD on dogs, and choosing a quality product. We’ll conclude with a list of resources where you can learn more about CBD.
How CBD Works In Your Dog’s Body to Modulate Pain
The endocannabinoid system (ECS) is an interconnected chain of receptors found in your dog’s brain, their nervous system, glands, and organs. Scientists don’t fully understand the ECS yet (it was only first discovered in 1992) but its believed to help maintain balance within the body.
All mammals—humans, dogs, and cats included—rely the ECS system to regulate immune response. CBD oil interacts with the CB1 and CB2 receptors in your dog’s body and acts as a natural neuroprotective agent with multiple health benefits. The cannabinoids in the oil open up two-way communication between endocannabinoid receptors to allow the body to either increase or decrease the immune response as needed. CBD oil is the natural way of regulating the system to maintain the perfect balance.
The reason CBD seems to help modulate pain is that many dog’s bodies are deficient in cannabinoids. Supplementing with CBD increasing cannabinoids in the body and restores balance to the ECS system.
RELATED: 10 Myths Regarding CBD Oil and Dogs
Is It Safe To Use CBD and Gabapentin to Manage Pain for Dogs?
In 2016, Colorado State University completed a pharmacokinetic and safety study of CBD on healthy dogs. This was the first clinical trial to demonstrate that the cannabidiol compound was absorbed by the dogs and measurable in the blood. The study suggests that CBD usage in dogs is safe enough to warrant more studies. Source
For the study, 30 healthy dogs were given 2 different dosages CBD in 3 different methods of delivery: capsules, an oil tincture, and a cream applied on the skin. The results showed that CBD given orally as a tincture was best absorbed and bioavailable to the body. (This is why we recommend buying CBD in a tincture as your first choice).
What Scientific Studies or Clinical Trials Have Been Done on CBD for Pain Management for Dogs?
In addition to the safety and absorption study mentioned above, 3 clinical trials have recently concluded with promising results. It’s important to note that the we’re still in the early stages of understanding how CBD interacts with the body, and much more research needs to be done:
1. Cornell University: Osteoarthritis Pain Reduction in Dogs: Cornell University researchers found that CBD supplied by ElleVet Sciences increased comfort and the activity of dogs suffering from arthritis, according to a study published in July of 2018. This clinical study suggests that 2 mg/kg of CBD given twice daily can help increase comfort and activity in dogs with osteoarthritis. Source
2. Liberty Leaf: CBD Research Study on Canine Pain Management: In August of 2018, results from a randomized, placebo-controlled clinical trial demonstrated that dogs with diagnosed osteoarthritis receiving a daily dose of only 0.3 mg per kg of a CBD-infused oil formulation for 4 weeks showed reduced pain and improved functional performance.
3. Colorado State University: Reduction in Seizures for Dogs with Epilepsy: For 24 weeks, dogs that experience at least two seizures a month received either CBD oil treatment or a placebo. Preliminary results released in July of 2018 showed that a 89% of the dogs studied showed a drop in regular seizures.
How Successful is CBD At Managing Canine Pain?
iHeartDogs commissioned a survey that was completed by 455 people who gave CBD to to their dogs. The following data represents the responses of dog owners who gave CBD for pain management:
Survey Question: How effective do you feel the product was for your dog’s condition?
You can view the full survey results here.
How to Choose a Quality CBD from Hemp Product for Your Dog
Choosing a high quality CBD product can be confusing since the market is currently exploding and your options appear endless. Unfortunately, many brands do not perform 3rd party batch testing on their products to ensure the efficacy and purity.
We’ve put together a buying guide for CBD, containing 8 things to watch out for before making a purchase. You can receive the CBD Oil Buying Guide by by requesting it below:
What Real Dog Owners Say After Using CBD for Their Dog’s Pain
We asked members the iHeartSeniorDogs Facebook community for their experience with using CBD to alleviate their dog’s pain:
Cannanine CBD is currently the only CBD oil approved and recommended by iHeartDogs.com
CBD has done wonders for our 11 year old Roti. You have to be very careful not to give them too much THC so choose your CBD carefully – Ken Tress
A lifesaver! I truly believe I would’ve already had to put her to sleep if not for it. – Suzanne Stanfield
The best thing I have ever done for my 200 pound Old English Mastiff was CBD oil she is 7 and we rescued her at 3 yrs old she was kept in a crate for 22 hours a day so she has terrible arthritis… so I medicate her 2 times a week and she runs and plays with my 2 puppers!! – Janell Michelle Cody
It’s been two weeks for our 13 year old pug and his hips are shot. His energy is back now, not jumping from pain when I pet him and is happy again. If I hadn’t tried this CBD oil I wouldn’t have believed it. Been a God send for my ole guy. I highly recommend it. Beats giving him pain meds which takes his spirit away. – Susan Johnson-Smith
I purchased Cannanine CBD oil for my two Bull Terriers for two different reasons. One is 8.5 yrs old and has arthritis. After a couple doses 1 per day there was an amazing improvement. She is up and playing and running around with my 2.5 yr. old. My 2.5 yr old is very excitable and we bring them both to our Sean soak campground. I tried it on her for calming effects. It seems to hit her the next day. Still experimenting with this. But for my 8.5 yr old it has brought back her quality of life. – Ann Fyfe
Some dog owners use CBD, but in addition to other supplements or prescription medications:
CBD and Gabapentin For Dogs
My dog is on Gabapentin along with CBD. No problems. – Mary Mueller
My dog is on Gabapentin and uses a 300mg cbd. It’s Really made a difference. He is 11. – Gene Sorensen
Good option but definitely not 1st line. Glucosamine Chondroitin MSM combo with Turmeric is a better 1st line options. Add CBD if this combo is not fully working by itself. –
My dog was on carprofen (generic rimadyl) and gabapentin for his arthritis pain. When I started him on cbd oil, I started with a much lower dose than what was recommended. Too much cbd too fast may cause issues like drowsiness or loose stool. While the cbd oil gradually increased, the other meds gradually decreased. As someone mentioned, it’s best to wean your dog off gabapentin slowly, don’t stop abruptly. My boy is only taking the cbd oil now and he is doing quite well. He even runs a little and he hasn’t run in years! Good luck with your pup! – Barbara Kalman LaVista
I am using Cannanine cbd oil along with turmeric paste. I couldn’t be happier with the results. – Pam Smith
Other dog owners saw results, but also had a few mild side-effects:
Fang (our 120lb..13 year old lab): has been on CBD oil for about 5- 6 weeks now and we’ve seen a noticeable improvement in his joint pain and overall movements. He’s able to walk up our 5 stairs with NO help and at times even takes off rather briskly up them. As of today, I would highly recommend CBD oil for older dog joint pain. We have noticed an increased appetite which has been a bit of a problem since he’s always had a rather enormous Lab appetite. We just focus on keeping his food intake the same to avoid weight gain…he can be a tiny bit hungry to be pain free. – Sinéad Daly Heath
One User’s Story: CBD for a 12 Year Old Immobile Dog
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Can my Dog take CBD Oil While Taking Other Medications?
With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.
In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.
Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.
Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.
CBD can alter the way your dog processes certain medications
Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.
CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.
There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.
You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.
Benefits of CBD Oil for Dogs
Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.
A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)
The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.
FDA & CBD
The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.
Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.
Blood Pressure and CBD Oil
High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.
A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:
The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”
CBD Oil Interacts with Anti-Seizure Meds
A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.
Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.
Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.
Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.
Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”
The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “
A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”
CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.
When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.
Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.
NSAIDs and Corticosteroids
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.
That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.
Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.
NSAID’S include the following:
Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.
Common corticosteroids include the following:
The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?
CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.