CBD Oil Side Effects On Liver

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Food industry news, voices and jobs. Optimized for your mobile phone. The liver is involved in a wide range of critical physiological functions. This article explores the ways CBD can affect our liver. One study on mice has led to some scrutiny over whether CBD oil could be harmful. So, should you be worried? Is CBD oil bad for your liver?

Study: CBD does not cause liver damage

Despite CBD’s popularity and increasing ubiquitousness, questions still linger regarding the safety and long-term impact of using the hemp and cannabis-derived substance.

Since hemp is now legal and CBD is becoming more mainstream, the FDA has come under pressure to clarify its stance on the ingredient so manufacturers eager to capitalize on the growing demand can develop products that can be sold.

A summer 2019 study involving mice suggested that there may be a link between CBD and liver damage. Critics pushed for a human study, like Validcare’s, saying there are differences between how CBD functions in mice versus humans, and most people would not ingest the level of CBD provided to rodents in the study.

The results of the study are likely good news for players in the CBD industry who may have been fearing heavy restrictions, should the results have raised red flags.

There are still plenty of other health-related questions about CBD to tackle. These stem from the relative newness of the ingredient and the lack of long-term research on side effects or how it may interact with medications. As a result, the FDA has cracked down on CBD-containing products making health claims or statements about what the ingredient can accomplish.

Consumers are showing increasing eagerness to add CBD to their daily regimens, with 40% saying in March 2019 that they would try CBD, according to a study by High Yield Insights. The ingredient got a boost during the COVID-19 pandemic, as consumers sought ways to relax, ease tension and improve sleep quality.

The lack of FDA regulations around CBD has not stopped companies from planning and creating products. These include completely new offerings and reimagined versions of existing ones. Unilever-owned ice cream maker Ben & Jerry’s was the first to hint at the possibility of adding CBD to some products after hemp cultivation was legalized in the 2018 Farm Bill. Soon after, Mondelez’s CEO announced that the company is exploring CBD snacks . Smoothie maker Bolthouse Farms has also expressed interest in developing a CBD-infused line of its drinks, but progress has been slow due to regulatory ambiguities , said the company’s vice president of marketing.

Drink makers seem to be leading the charge when it comes to getting CBD products on store shelves. Ocean Spray’s Lighthouse incubator launched a line of sparkling CBD water called CarryOn, while Constellation Brands’ Canopy Growth launched its own bubbly CBD beverage, Quatreau . Truss CBD USA, a partnership between Molson Coors Beverage Company and Canadian cannabis grower Hexo, has also debuted a sparkling CBD drink called Veryvell in the U.S.

With the number of states legalizing cannabis increasing and a new administration that appears more favorable toward the substance, momentum around CBD is gaining speed. Manufacturers have little reason to stop making CBD products to satiate growing consumer demand, but the FDA has a critical role to play in determining how many of them will come to market.

CBD & Liver Damage: Learn If CBD Can Actually Affect Liver Functions!

Studies show a higher prevalence of liver cirrhosis or liver damage in the United States of America than before. It is an important health concern and a significant reason for morbidity and mortality.

Due to the prevalence of liver damage, the use of CBD oil has grown in popularity across the United States. The public has become more aware of the health benefits and the possible adverse effects of CBD usage.

Can CBD Cause Liver Damage?

CBD oil has a low risk of side effects, thus. Researchers used daily doses of 1,500 mg to 3,000 mg CBD to examine the safety and effectiveness of CBD in humans. A sample group took a dose of 1,500 mg of CBD for six weeks; scientists identified no life-threatening negative effects.

Recent research on mice in 2019 found that increased dosages of CBD can harm the liver, garnering significant media coverage. The study also caught the attention of people who have been seeking a major side effect to disprove CBD’s therapeutic potential. Like every other medicine, CBD does have its side effects, but the real question is if it is harmful to liver function when taken in an average dose.

  • Effect Of CBD On The Liver Of Mice

The University of Arkansas conducted research on a group of 8-week-old mice to study the treatment of various dosages of CBD. The research had a problem: there were not enough extensive toxicological studies on CBD safety. It was crucial to establish the effects since companies continue to market CBD and CBD-derived goods.

Likewise, when scientists give mice repeated doses of a lower concentration of CBD (50 mg), it results in liver damage and edema. Due to the difference in the physiology of humans and mice, the size of the liver is one of the many aspects that they must consider. When analyzing the benefits of CBD in human beings, it is vital to know how far these differences fare.

According to previous studies, CBD products, when prescribed to adults, resulted in elevated liver tests. Hence, scientists conducted a study to compare the occurrence of higher liver tests in an adult population who self-administer CBD to the average and general adult population.

Studies concluded that people who self-administer CBD for various ailments did not appear to have increased results in their liver tests. However, the underlying diseases or medicines taken to treat these conditions could be the main source of the anomalies. Self-medication of CBD, when taken in controlled amounts, was not linked to clinical liver damage in adults.

Is CBD Good For Fatty Liver?

All mammals have an endocannabinoid system consisting of (CB1 and CB2) receptors. CBD interacts with ECS and helps in mood, appetite, sleep, and memory regulation. The body naturally produces endocannabinoids. These molecules bind to the C1 and C2 receptors, found in the central and peripheral nervous systems, respectively.

The body’s ability to stabilize and adapt happens in the ECS. The ECS controls homeostasis to maintain balance. Moreover, this network regulates the equilibrium of the body’s many systems and organs, including the liver.

When the liver gets injured, inflamed, or malfunctions, the body’s response is to produce more endocannabinoids. The ECS’s activity is mainly associated with a healthy liver. In fact, the ECS components in the liver are low in concentration.

Emerging evidence indicates that cannabinoids play a key role in fatty liver regulation. They are mediated by cannabinoid receptor activation.

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While researchers are still looking into how CBD interacts with the ECS, most results are mainly based on assumptions. But they believe that the endocannabinoids take time to break down. Hence, it enhances the functions of these neuroreceptors in the body.

Can CBD Oil Help People With Liver Cancer?

Studies about cannabis and its efficacy in liver cancer reveal that it can deter tumor cells from spreading. Moreover, scientists revealed that it could destroy cancer cells while preserving healthy cells. CBD Oil is used in various ways to help fight liver cancer and prevent cancer growth. First, it acts as an anti-metastatic agent, inhibiting the development of reserved tumor masses in the liver. Second, it inhibits the growth of new blood vessels, which aid cancer progression.

CBD causes pre-programmed cell death. Scientists discovered this ability while studying the effects of CBD in animals. These anti-cancer features apply to both CBD and THC.

Cannabidiol For Viral Hepatitis

Viral hepatitis B (HBV) and hepatitis C (HCV) are grave public health concerns worldwide. Both viruses induce severe liver damage if left untreated, resulting in cirrhosis and cancer. Unlike HBV, which has a vaccination, HCV does not. The potential of drug resistance and the high cost of existing medicines led to the discovery and development of cost-effective medications.

With the recent spike in interest in medical cannabis CBD, scientists kept pushing to discover more of its benefits. Researchers are looking into analyzing and verifying the therapeutic potential of CBD liver function.

They found CBD to limit the multiplication of the hepatitis C virus by nearly 90% in a study published in the Journal of Pharmacognosy Research. They concluded from this research that CBD has the potential to be further researched as a treatment for viral hepatitis. Moreover, people can use it as a combination therapy with existing medications.

CBD For Hepatic Ischemia

Hepatic ischemia is a prevalent complication of liver surgery and transplant. It causes the liver to be severely inflamed and can even lead to transplant and rejection-related mortality. Moreover, oxidative stress can aggravate the patient’s condition.

Scientists found that CBD has antioxidative properties. Further, it also has anti-inflammatory effects. Thus, it could help to reduce inflammation and protect the liver from oxidative damage. Researchers found that CBD efficiently reduced inflammation and oxidative stress during experiments in labs. Not only that, but it also caused an increase in malignant cell death in the liver. According to other studies, when scientists treated rats with hepatic ischemia with CBD, it resulted in a considerable reduction in liver damage.

CBD For Liver Encephalopathy

Hepatic encephalopathy is defined by psychological disturbances that occur due to liver malfunction. Personality changes, confusion, and movement issues are just a few signs. In severe circumstances, it can lead to a coma.

This condition is usually caused by inflammation. Scientists conducted a study on mice with hepatic encephalopathy to determine the therapeutic effects of CBD oil. They found that CBD oil restored neurological function and cognitive capabilities. CBD also helps restore liver function and regulates the overall level of liver enzymes by lowering ammonia levels in the blood.

CBD For Autoimmune Hepatitis

Inflammation of the liver causes autoimmune hepatitis to an already compromised immune system. The TRP (transient receptor potential) is a set of membrane proteins involved in transmitting various chemical and physical signals.

Studies report that when TRPV1 is activated, it lowers the inflammation of the liver by activating myeloid-derived suppressor cells (MDSCs). Hence, blocking the inflammation leads to autoimmune hepatitis.

According to research, CBD causes the TRPV1 receptor to activate. Not only that, but it also helps in reducing inflammation and pain due to the proliferation of T cells. It is safe to say that CBD can help prevent and treat autoimmune hepatitis.

Hemp For Alcohol-Induced Liver Fibrosis

Liver fibrosis happens due to constant liver damage caused by overconsumption of alcohol. Chronic alcohol abuse eventually leads to liver cirrhosis.

Scientists found that CBD has anti-fibrosis characteristics. It hinders the production of collagen by cells that cause fibrosis. Moreover, it can also help to counteract the effects of alcohol-induced liver damage.

Does CBD Oil Affect Liver Enzymes?

There have been conflicting results of studies on CBD oil’s effect on liver function. According to one study, 10% of the participants had increased levels of liver enzymes and had to quit using CBD as a result. Scientists found that CBD improves liver function in other trials. To avoid any possible CBD-drug interactions and minimize liver stress, individuals with liver disorders should limit their use of over-the-counter (OTC) drugs. If the individual does not exceed a dose of 20 mg CBD/kg/day, CBD is typically safe for liver function.

Dosage Of CBD For Correct Liver Functioning

There is no right amount of dosage when it comes to CBD and liver. Most human medical trials that suggested precise CBD dosages have been conducted on anxiety, chronic disorders including epilepsy, and multiple sclerosis models. There is yet to be a clinical investigation that looks into CBD’s effects on various stages of liver diseases. Moreover, researchers have yet to determine a proper dosage for this condition.

The ideal dosage of CBD for each person is defined by several factors: weight, age, and gender. Moreover, you also have to consider the intensity of the symptoms, one’s metabolic rate, and experience with CBD products.

The best method is, to begin with a minimal dose and slowly increase it until you achieve the desired relief. We suggest starting with 5 to 10 mg of CBD and evaluating the results for one week. If you believe the amount is inadequate, you can increase the dose to 5 mg and continue for another week, reevaluating the outcomes.

It would be best to ask a physician to measure the most suitable dosage range for you. Also, they should assist you in avoiding possible drug interactions if you are using medication.

Benefits And Side Effects Of Hemp For Liver

CBD can help reduce feelings of anxiety and sadness, control PTSD symptoms, and ease chronic pain. Moreover, it offers protection against some neurological disorders. General enhanced brain, heart, and healthy skin are possible CBD oil advantages. However, researchers need to conduct more studies to figure out how CBD affects these ailments.

On the other hand, the evidence from consumers that the benefits of CBD are many. Further, CBD may provide these benefits without the euphoric symptoms associated with marijuana. Even though some CBD products contain trace levels of THC, these amounts are trivial compared to the amount required to feel high.

CBD oil may be a helpful approach to improving your quality of life. If you are looking for a way to relax after a hectic day at work, CBD may relieve that stress. If you seek treatment for chronic pain and muscle spasms, CBD may help reduce the sensation.

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Negative Effects Of CBD

CBD offers a high level of safety. People turn to CBD as a low-risk alternative to traditional liver disease treatment methods. But, when ingested in excessive dosages, it causes a few side effects, including:

  • Dizziness
  • Gastrointestinal problems
  • Fatigue
  • Dry mouth
  • Appetite changes

Some of these adverse effects may occur due to an overdose. Also, ingesting an incorrectly labeled product with more than 0.3% THC can cause such side effects. Lastly, if one obtains CBD from low-quality hemp or is processed with harsh solvents, one will suffer from adverse reactions. When taking high-quality CBD oil daily, the mentioned adverse effects are almost non-existent.

Best CBD Oil For Liver Issues

#1. Flavored Hemp Oil By BudPop

BudPop offers two varieties of CBD oil that include peppermint tincture and natural CBD. The tincture comes in a 1 fl oz glass dropper bottle. Each bottle contains 1,500 mg of CBD and 50 mg of CBD per serving. Further, ingestion is simple because all you need to do is place a few drops of the product under your tongue.

The tincture contains no synthetic compounds or preservatives. It is organically flavored with peppermint and has been lab certified for purity and strength. The tincture is composed of CBD from organic hemp, natural peppermint oil, terpenes, sucralose, and water. Each bottle contains 30 servings which can last you a month or more depending on usage.

BudPop CBD uses hemp farmed in the United States. Both peppermint and natural CBD tinctures contain natural terpenes for that smooth and rich taste. You can use the dropper to measure the amount of oil. Drop the oil under your tongue and hold it for at least 20 seconds. It may take some time for the oil to take effect, and when it does, you may experience a pleasant and soothing calm. You can also change the dose by ingesting a different quantity of drops.

BudPop recommends keeping the tincture in a cool, dry place away from sunlight. They back their products with a 30-day money-back guarantee. Hence, you can return them if you feel that the product is not working for you. However, they only allow returns for unopened products.

#2. Full-Spectrum CBD Oil By Exhale Wellness

Exhale Wellness offers a full-spectrum CBD oil. Its oils are non-GMO, free from preservatives, organic, and made of 100% natural ingredients. Exhale Wellness’s full-spectrum CBD oil comes in a clean glass dropper bottle, and it is available in 600 mg and 1,200 mg. Exhale Wellness offers premium hemp products that are lab tested for accuracy and derived from legal complaint hemp. All products are not tested on animals and are cruelty-free. Exhale Wellness offers a 30-day money-back guarantee and 20% off on the first purchase.

How To Consume CBD Tinctures

Most manufacturers sell CBD oils in 30 ml glass dropper vials, which contain around 30 doses of CBD. You can prolong the shelf life by keeping it in a dry, cold, and dark environment away from light. Many CBD users agree that consuming a tincture is one of the simplest techniques to ingest CBD oil due to its easy packing. You only need a few drops sublingually and wait for them to work.

The best method for ingesting CBD oil is sublingual. Hold the oil below your tongue for at least 20 seconds before taking your dose. While the oil is resting under your tongue, the CBD is absorbed by the thin mucus membranes. It avoids digestion and rapidly enters the circulatory system. Holding the oil under your tongue allows the oil to permeate your system quickly. You may feel the results sooner if you keep it under your tongue rather than ingest it.

However, some users may need extra time to select their ideal dosage, and some users may dislike the taste of oils. The natural bitterness of hemp compounds most likely causes it. That is why many companies use various flavors to cover the taste of hemp. Some consumers also report a burning or tingling sensation while using the oil. While this is not hazardous, it may cause CBD users to seek out different methods of consuming the product.

FAQs: CBD Oil & Liver Functioning

#1. How Long Would It Take For CBD Oil To Work?

Several factors determine the time consumed for CBD oil to work. Because everyone is different, an individual’s biology can influence, to some extent, how long it takes for CBD oil to take its optimum effect. You must consider the person’s metabolic rate, age, fitness level, and tolerance.

First, hold the CBD oil under your tongue to allow the oil to enter your mucous membranes. It may take approximately half an hour to know the effect of CBD oil in this manner. It is one of the easiest ways to experience the benefits of CBD oil.

Then there is the alternative of simply swallowing the CBD oil or mixing it with food or drink. You can take it along with your food or drink instead of using it sublingually, but you will have to wait for the effects to kick in. It is totally up to you to decide how to use CBD oil based on your preferences and needs.

#2. Why Should We Use CBD Tinctures?

CBD tinctures can be effective in a variety of ways. CBD products may be pretty efficient at relieving pain in the body. The ECS system is a unique mechanism in the human body. It helps the body govern many functions and activate specific immunological responses. Moreover, this system regulates bodily activities like eating, pain sensation, and sleep.

#3. Isolate, Broad-Spectrum, And Full-Spectrum CBD Oil – What Is Their Difference?

Full-spectrum CBD contains all of the components present in hemp plants, including THC, the chemical that causes a high. In broad-spectrum CBD, the hemp plant includes a number of components, including CBD, but no THC. While you will still receive many benefits, they will be less intense owing to the lack of THC. Isolate CBD is the purest form of CBD. It is purely made of CBD, and no other compounds are present.

#4. What Are The Benefits Of Buying BudPop CBD Oil?

BudPop uses hemp grown in the USA. The hemp used in their oils is organic and free from toxins and heavy metals. The BudPop CBD tinctures are available in two flavors. It is potent and contains legal amounts of THC. Moreover, BudPop offers Certificates of Analysis for its goods, including detailed information regarding their effectiveness, durability, and purity. BudPop provides quick and easy shipping; they will pack and ship your orders immediately and at no extra expense.

Final Thoughts: Does CBD Prevent Liver Illnesses?

Research has shown that CBD effectively treats various severe liver illnesses, including fatty liver disease, liver cancer, fibrosis, and cirrhosis. High-quality CBD oils offer lots of benefits. Its effectiveness may be therapeutic in various ailments involving liver malfunction. Moreover, it may help to substitute long-term use of certain drugs. A high dosage can cause liver toxicity. Hence, we advise patients to seek medical advice before introducing CBD into their lifestyle. Discuss the dosage and set the best time timetable to avoid probable drug interactions.

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Is CBD Oil Bad For Your Liver? Here’s What You Need To Know

Any new supplements you are considering adding to your diet should be looked at carefully. Do they fit with your lifestyle? Will they interact with any prescription medications you’re on?

Our extensive research – and that of scientists across the globe – has proven that CBD oil is well tolerated by the human body and that it has very few, if any, side effects.

Taken by itself, there is no negative impact on core functions such as digestion, heart rate or glucose levels, even with higher doses of CBD oil (up to 1,500mg per day).

But one lone study on mice has led to some scrutiny over whether CBD Oil could be harmful to the liver, affecting how it functions.

So, should you be worried? Is CBD oil bad for your liver?

What Is CBD?

CBD is short for cannabidiol, the non-psychoactive chemical compound found inside the cannabis plant. It’s used as a supplement to help support a balanced diet and a healthy lifestyle, and is most commonly taken as oil drops under the tongue, but can also come in other forms such as absorption drinks and creams.

Despite its roots in the cannabis plant, CBD oil is legal to buy in the UK and in many other countries across the globe, and many consumers claim it’s effective for pain relief, combating nausea, stress, with more than a third of CBD oil users claiming it helps with their anxiety.

Cannabidiol interacts with and supports the human endocannabinoid system by binding to the receptors found in the body’s nervous system.

These receptors pass messages through pathways in the human body to keep the body well balanced, and the endocannabinoid system helps to regulate hormones, sleep patterns and mood, as well as things like appetite and immune response.

What Does Your Liver Do?

The liver is a metabolically active internal organ in the human body. It holds more than 10% of your total blood supply and actually has more than 500 different functions. The three main functions are that it cleans the blood, produces a digestive liquid known as bile and stores energy.

Bile aids digestion in the small intestine by breaking up fats into fatty acids. The liver works to transform all the nutrients we ingest into something the body can use, stores these substances and then distributes them around the body when and where they are required. It also converts toxins into harmless waste products that the body can then get rid of.

To keep your liver healthy you should eat a balanced diet, keep to a moderate alcohol consumption, exercise regularly, maintain a healthy weight and avoid recreational drugs.

The liver is the only organ in the human body that can regenerate itself. If the liver is healthy and a quarter of its tissue remains in place, it can regrow to its original size within just a few weeks.

Excessive intake of alcohol, fatty food, sugar and salt can all be damaging for your liver. Overindulging in these things can result in numerous problems, including liver failure.

Signs that your liver isn’t working properly include yellow skin or eyes, known as jaundice, abdominal pain or bloating and swelling of the legs and feet.

Will CBD Oil Hurt Your Liver?

Following a single study on mice last year, there have been concerns about CBD oil possibly being damaging to your liver if it is used in high quantities.

However, in the study in question, the doses used for the mice were much higher than humans would take, so the small daily drop of CBD oil which is advised for people is highly unlikely to cause the same effect. Therefore the study doesn’t mimic the typical intake of a CBD user. Scientists have instead said the findings can give an indication of the consequences of a potential CBD oil overdose.

It is the same with any drug or supplement. If you take more than the recommended dose there are always possible consequences, whether it be an excessive dose of grapefruit extract or ibuprofen. Studies have shown that using more than the recommended dose of ibuprofen, for example, can cause stomach ulcers and other gastrointestinal problems as well as greater risk of cardiovascular concerns.

And – obviously – a mouse is not a human being. Although they share very similar genes, which is why mice are frequently used for testing purposes, they are physiologically very different and this must be taken into consideration.

Further research into the findings has shown that using the correct dosage of CBD oil is safe for widespread use, and is well tolerated by the vast majority of people.

This is backed up by the World Health Organisation, no less. Not only that, but conflicting research has shown that the therapeutic properties of CBD oil could actually help improve liver function because of the way it interacts with endocannabinoids to create anti-inflammatory and antioxidant effects.

Can CBD Cause Liver Failure?

As CBD Oil is so new to the market, there is still much research to be done into what it can do, how it can potentially help users and any undiscovered risks involved.

However, initial findings suggest that side effects are minimal and it is only if you take a comparably huge dose of CBD Oil that your liver could be affected.

There are three main things to cause liver failure – obesity, alcohol misuse and hepatitis. CBD is not one of these and nor is it currently deemed to be a contributory factor.

The Bottom Line

Taking the correct, recommended dose of good quality CBD pil as part of a general wellness routine is unlikely to cause any side effects, including liver damage. Any side effects reported in humans up to now are very rare – and very mild if they do occur.

Vitally, if you are a CBD consumer, ensure you buy from a reputable source with lab certified products who can verify their contents. If you are already taking any form of medication we advise that you consult your doctor or healthcare professional before taking any CBD Oil or related products.

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